Interesting article, I'm very new to the field but I have an exciting application for GIS--I'm a biologist at Harvard and we have a new method to generate biological measurements at atomic scale inside biological specimens, and I believe the best way to store and analyze this data is using a GIS. Consider the example in your paper; "What are the optimal aircraft settings for my aircraft in this weather?” For our data, the questions are more like "What is the molecular spatial architecture of this tumor, and how can that inform treatment?" If this seems interesting to you it would be great to have a conversation about ways SpaceCurve could advance our project.