I wonder what the effects of other arylcyclohexylamine compounds have on depression. There is plenty of anecdotal evidence on Bluelight.ru and Erowid.org suggesting that other chemicals of this class can have a positive impact on depression. Of course, there are plenty reports of addiction and negative behavior (mostly with PCP). I know that many people report the legal analogue Methoxetamine (legal in the US; Ketamine is schedule III and the federal analogue act only applies to schedules I and II) has potent antidepressant effects.