However, the relation between how much is there to know (increasing) and how much fits in a head (constant) is growing, which is sad, and whether it has ever been 1 seems rather unimportant to me.
The fact that the ratio continues to grow seems like a fundamental property of technology -- personally I don't find it sad. In exchange for more powerful tools, you inevitably need to accept more levels of abstraction and more underlying complexity.
The ratio of things we know to things we don't know is essentially zero. Thankfully that doesn't preclude us from dreaming big and accomplishing great things.