Heck no, but NoScript allows you to permanently white list domains and there is a pareto like distribution of domain usage.... white list for a few days and most of the internet works. By then you've gotten in the habit of twiddling with the NoScript menu wen it doesn't. And you start noticing how many domains that are just designed to serve you ads, spy on you, and God knows what (like unregistered IP addresses) you are avoiding granting access to.
There are only a few situations where it's a challenge. First, when there are just so many third party domains that is is pragmatically difficult to quickly weed out the ones that are making your experience better vs. worse. Second, when the third party domains dynamically load 4th party domains NoScript seems to puke, although it's getting better. If you visit some of the 3rd party domains though, you can sometimes figure out what the 4th party domains are and enable them.
Once in a blue moon, I do just have to view a site in Internet Explorer lol.
A surprising amount of stuff does still work with JS "effectively disabled" though. And even if you don't whitelist domains, NoScript will still turn of flash and let you "click through" to enable individual videos and stuff. It's a refreshing (and speedy) experience not to have to much "flashing" at one.