This is one of those anecdotes that just pollutes discussions, allowing people to cheer on their biases. My anecdote is that Visual Studio deals with very, very large projects with gusto (albeit far below the absurd "hundreds of millions of lines of code" scenario described by someone else, which if in one solution borders on insane). The CLR has worked ridiculously well for years on end with nary a hiccup in sight. And so on.

Visual Studio isn't perfect, nor is any IDE (Eclipse...xcode...Geez, turn on the coffee machine because we'll be spilling complaints all night long).