AOT is a little fussy in real-world usage particularly for things like reflection. You can probably force it to work but it may make your code much uglier.
Span<T> is more important for performance TBH JIT warmup isn't a huge issue for a long-running process
Flip side is that if you use more source generation, it may end up making the code more terse/"prettier" where it matters and avoid the reflection hit.
AI agents seem fairly good at generating source generators so there doesn't seem to be a reason to not use them.
Only a subset of reflection is actually AoT safe, and you can run into issues like "the method you wanted to call wasn't statically referenced anywhere, so there is no compiled implementation of it".
That's due to trimming which can be also be enabled for self-contained builds that use JIT compilation. Trimming is mandatory for AOT though. But you can use annotations to prevent trimming of specific thing.
AOT doesn't support generating new executable code at runtime (Reflection.Emit), like you can do in JIT mode.
Span<T> is more important for performance TBH JIT warmup isn't a huge issue for a long-running process