86Box runs on modern MacOS, but is not very performant for games on ARM.

https://github.com/86Box/86Box

There are also patch sets available for modern PCs to support legacy MSDOS, and Windows 3.1/95/98/ME. Attempting to install/run on modern hardware will usually blue-screen without the workarounds. =3

https://github.com/JHRobotics/patcher9x