If your threat model needs to include “I’m (going to be) a target of major nation-state intelligence community agencies” then it’s safest to assume none of this is going to prevent them getting your data?
It's going to make it more difficult for them which in aggregate will prevent them from obtaining all the data they want without spending more resources to get it.
It's also going to put more money into the pockets of non American alternatives which will in turn give them more resources to spend on making more secure offerings.
If you're a business worried about a foreign state actor stealing all your corporate secrets, using a Microsoft/Google/Amazon product is functionally the same thing as letting China have a backdoor into your company. The current US regime didn't actually change anything for a European company, but it's more obvious now, plus AI has made the vampires hungrier across the board.
James Mickens covered this at Monitorama 2014 in a humorous way. https://vimeo.com/95066828 (16:30)