Basically every game is written in C on a modern processor (MIPS) so i highly doubt it. Maybe some weird homebrew stuff like that flappy bird video uses it but emulators tend to deal with problems like that by ignoring them (e.g. IIRC there is no emulator that can properly run that N64 linux port from a few years ago, and there have been plenty of SM64 glitches that work differently on emulators vs real hardware)