This made me think back of the days of +Orc [1]. I believe a lot of knowledge common back then, like how to find and nop out an undesired branch, has been lost. Which is fair, there’s way more other tech to learn nowadays.
I always feel nostalgic when I see references to +Orc, or Fravia (RIP).
But I think there's still a lot of people doing the NOP-patching thing, albeit with more complexity. There continue to be people breaking DRM, and investigating random [mobile] apps with hex-editors & etc.
It's harder to get started these days as programs are more complex, but at the same time the knowledge required is more accessible.
[1]: https://en.m.wikipedia.org/wiki/Old_Red_Cracker