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Some stuff I know:

Django is great for learning very fast. It has all the documentation in one place. There's generally one way to do any one thing with Django.

Pyramid is super flexible because it's not much of a framework to begin with. Think of it as glue to stick together a bunch of components to handle specific parts of your app (like database ORM, cache, sessions etc) and you can use any components that you like. Pyramid is harder to pick up than Django though because of this reason.

Pyramid is faster than django on benchmarks I've seen on the web (but this will hardly matter in the real world in my opinion)

Both have some big projects executed using them(Disqus is written in Django and Reddit is written in pylons for examples)

There are a bunch of other python frameworks that I haven't used yet so I can't tell you anything about them.

I'm currently working on something using Pyramid so if you have something specific you want to know, I'll try and answer (I'm new to this too)

I'd recommend learning django first though. It's what you should look at if you want a quick inroad into python web frameworks without much time spent learning.



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