AdGuard as the DNS for your router + Tailscale blocks trackers and ads on all your devices in all apps, not just browsers with ad block installed. Mobile games, embedded WebViews, etc. If you are an iOS user that hates safari, you can use Firefox without ads. Something like 30 percent of what it blocks in my logs comes from trackers being blocked on my Roku and Android TV. With Tailscale it will also block ads when you are mobile.

The one caveat is that it does not block ads served natively, so you will still need a specialized app for native YouTube, Instagram, and others, but those are readily available now.