It does, either via AuroraStore (complete Google Play Store replacement without google account) or Sandboxed Google Play [1]. My banking apps works, and everything else I can think of.
Hard to say what a "normal" level of tinkering is with Android, as I have switched directly from iOS to Graphene and have never used Stock Android. I am sure some things are a little bit more cumbersome, but for me the tradeoff is worth it.
Also the stock g-cam (with internet access disabled) and g-photos (with internet access disabled) make a pretty amazing photo and photo editing experience.