After reading the article last night. I spent the whole evening about 5 hours getting one of my DOM libraries to compile with mypyc. It's a hacky codebase with little to no type hinting. I had to rewrite a fair abit to appease mypy and in most cases just used 'Any'. It's still got runtime issues and is buggy but I got at least a 2x speed increase on rendering a single node... https://github.com/byteface/htmlx/blob/mypyc/benchmarks.md

However I was unable to compile from my mac, could only compile using linux. but that could be as I'm using older version of dev tools.