Hacker Newsnew | past | comments | ask | show | jobs | submitlogin

> Psychedelic enthusiasts can be even worse in this regard.

Oh yes, I've had a run in with a "psychedelic enthusiast", and this is so accurate. It was my girlfriend during my late 20s, a woman who was 12 years older, very into psychedelics, and pretty obnoxious about how beneficial they were. Of course, at the time I ate it up because I was kinda lost in life, and let her overcome my better judgement with her guru bullshit.

I'd previously only ever used marijuana, and had mostly negative experiences resulting in anxiety, so had mostly sworn off the idea of trying psychedelics until she came into my life. Long story short, I tried mushrooms once with her, fun for a bit, but then led into a crazy making spiral leading me to be convinced I'd never be the same.

I guess I was a glutton for punishment back then, because I also tried LSD with her twice, and it had pretty similar results. In fact the second trip shook me up in such a bad way that I think it took nearly a year to get the negative bits still remaining out of my head.

Of course her reaction after all this was that I was being too resistant and that I simply needed to have a "corrective experience". Fuck that! She seriously couldn't comprehend the fact that everyone reacts to psychedelics differently and that they might be quite dangerous for some people. Which seemed kinda crazy because she was actually highly intelligent, but possibly too arrogant to look outside her world. I seriously could have ended up in an institution if I had stayed with that woman (can you tell I'm venting a tad :) ).

I've later come to learn that I have a genetic mutation that reduces my ability to degrade dopamine in the prefrontal cortex by 75% (COMT met/met), leading to much higher baseline dopamine levels. After learning about this, it makes a ton of sense why I have such bad experiences with dopaminergic drugs like caffeine and Adderall (euphoria followed hours later by intense anxiety). Now I don't know how LSD and mushrooms impact the domaine system, but it does make me wonder if this genetic SNP, partially explains my propensity to anxiety/psychosis on these drugs. High baseline dopamine leads to hyperfocus, which is great for coding or other technical work, but terrible when you're stuck in a spiral of thinking you're going crazy and will never be the same.



Guidelines | FAQ | Lists | API | Security | Legal | Apply to YC | Contact

Search: