I actually like monospace pixel fonts. Doubt it would make a difference. I have a (cheap) 4k display at home. Some things might look better, but I would recommend to use one with a high refresh rate and good contrast.

Since I used ebook readers with their displays, reading on a monitor is always a compromise in comparison.

Wouldn't want to go lower than 1080 though. It can work of course, but it just doesn't have to be.