Hah bam files are the pinnacle of engineering compared to the clusterfuck that is VCF: GT or PL? Ploidy? Enumerating all possible ALTs but some with 0 AF? And then you have mutations in cis, try to merge them. Which assembly - you can guess because it doesn't have to be specified. You also don't have to specify your transcripts and of course you have better defaults than everyone else. How many different formats for annotating mutation effects are there 10? 20?
With webdev I can at least stick with jquery and do no harm
> With webdev I can at least stick with jquery and do no harm
The amount of time saved by doing this would be immense based on my experience inheriting maintenance projects in Anglaur / React / whatever flavour of the month framework was used. They may seem productive when developing, but trying to fix bugs in them can be an absolute nightmare.
With webdev I can at least stick with jquery and do no harm