Since you're trying to hire developers, you are undoubtedly aware that roughly 100% of the people who apply for your job are completely unqualified to program computers. Anything you can do to narrow that stack of 300 incompetents down to the 4 you can actually interview is worth doing.
So yes, ditch anybody who can't be bothered to proofread their resume. As other people have said, communication is an important skill for a developer. You have in your hands proof that they're not particularly good at it. Toss it and move on.
I think this is the key issue for me. My wife is a PhD but admits that she can't spell. However, she has others look over any important documents or emails before sending them out. Someone who won't do this for something as important as a job application communicates (to me) either arrogance or troubling lack of self-awareness of their weaknesses.
Since you're trying to hire developers, you are undoubtedly aware that roughly 100% of the people who apply for your job are completely unqualified to program computers. Anything you can do to narrow that stack of 300 incompetents down to the 4 you can actually interview is worth doing.
So yes, ditch anybody who can't be bothered to proofread their resume. As other people have said, communication is an important skill for a developer. You have in your hands proof that they're not particularly good at it. Toss it and move on.