People frequently seem to think this is about the line number it's on (666), but that doesn't have anything to do with it. That line number is a totally modern construction; the original source code was on punch cards. That particular comment was punched onto card number 0562 in the LUNAR LANDING GUIDANCE EQUATIONS log section. The original developers only referred to code by punch card number, and page number in the listing. So it really is just a coincidence, and the "NUMERO MYSTERIOSO" is referring to whatever is in GAINBRAK,1.

It should be 1. "GAINBRAK,1" is assigning 1 to GAINBRAK.

No, it's not. The 1 here is using interpretive index register X1 to index onto GAINBRAK. The star on the DMP means that multiplication is indexed. GAINBRAK is one of the pad-loaded descent targeting parameters; the index selects the appropriate number based on the phase of the descent.

One heck of a coincidence.