Definitely. It would be surprising if genetics affected almost any of these problems tbh. Much more likely is that the damage arises in a poisson ransom process or whatever and we have little recourse
Also, IMHO it’s a bit arrogant to believe we know the best traits. Humans are complicated systems. Maybe halfblind, motion sick and paranoid people are better at surviving out there than happy contempt people never bothered when the centrifuge breaks down. Or whatever. I agree that the best brute force test is to just put a lot of people up there and see what happens. The best survivors might not be the obvious candidates.