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https://en.wikipedia.org/wiki/Caffeine#Adverse_effects

Not brain damage per se: > Caffeine can have negative effects on anxiety disorders. According to a 2011 literature review, caffeine use is positively associated with anxiety and panic disorders. At high doses, typically greater than 300 mg, caffeine can both cause and worsen anxiety. And > Caffeine-induced anxiety disorder is a subclass of the DSM-5 diagnosis of substance/medication-induced anxiety disorder.

However I will note that it does list a bunch of positive effects of caffeine use; including reduced risk of depression ("although conflicting results have been reported").



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