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User @shusaku refers to MDPI as a "garbage journal". If true, this info should play a bigger part in the discussion here than it currently is



why? it still links to MDPI.


Wait, was your combo shot one of each? or two of each? I've been curious to learn more about getting both (already had two Pfizer) but resources on the matter are hard to find


Some Canadian provinces treated mRNA vaccines as interchangeable. In Ontario a lot of people got a first dose of Pfizer and a second of Moderna.

There's currently a study underway in the UK (I forget the name, but it run by the University of Oxford) to assess the efficacy of mixed-dose vaccination.


More than mRNA vaccines as interchangeable, we (Ontario) mostly treated the oxford vaccine as interchangeable with the mRNA vaccines too, until we started giving it to less people.


Not gp, but I'm also a Canadian with the covid-cocktail. I got my Pfizer back in May, and then my Moderna at the beginning of July.

Some of the older (55+) crowd got a different mixture, with AstraZeneca shots in the early spring and Pfizer early summer.

Say what you will about our weird combos, but we have a very high number of people immunized now, so it seems to be working...


Same here in Canada. I got Pfizer through public health followed by Moderna 8 weeks later at a walk in pharmacy.


I’m Canadian and had one shot of AZ as a first dose. Followed by one shot of Moderna maybe 10 or 11 weeks after the first does of AZ.


Many Canadian provinces did a Moderna/Pfizer combo (one shot of each) to address shortages and get more people fully vaccinated faster.


It sounds like they were really following the science, and trying some new stuff along the way.


Yes, you should have seen how much complaining it generated!


The best combo so far (June) was AstraZeneca first then Pfizer (not the opposite, nothing then about Moderna), the next good one will be probably intranasal AstraZeneca after some mRNA:

Mixed Oxford/Pfizer vaccine schedules generate robust immune response against COVID-19, finds Oxford-led study: https://www.ox.ac.uk/news/2021-06-28-mixed-oxfordpfizer-vacc... ,

.. https://science.sciencemag.org/content/373/6553/397 - "the ideal vaccination strategy may use an intramuscular vaccine to elicit a long-lived systemic IgG response and a broad repertoire of central memory B and T cells, followed by an intranasal booster that recruits memory B and T cells to the nasal passages and further guides their differentiation toward mucosal protection, including IgA secretion and tissue-resident memory cells in the respiratory tract." .. (https://news.ycombinator.com/item?id=28019151),

https://news.ycombinator.com/item?id=28016821 - Covid-19 Vaccine Intranasal Study (COV008), UK phase 1 trial recruiting,

That said, current vaccines don't provoke the exact same response as an actual infection, particularly in that they don't fully stimulate an immune response in the mucous membranes of the upper repository tract. Here's an Scientific American round-up article (from back in March): https://www.scientificamerican.com/article/to-beat-covid-we-...

[..]

The current vaccines are excellent at helping the body stop the virus as it progresses into the lungs and further (thus the massive reduction in severe illness and deaths). But it still means that there's a period of a few days after initial infection when a vaccinated person has a relatively naive immune response (while the virus is mostly just in the nose/throat). This would then result in the person still being pretty contagious. (https://news.ycombinator.com/item?id=28014448).

I would like to see intranasal Novavax (intranasal mRNA is more difficult ?), having good results, as an option to this mix..


This may sound unhelpful, but if you have good enough organic growth somebody may post it in the subreddit (and many other places) without your prompting


No worries, I’m assuming you don’t have that yet.


Most likely, if you're posting on HN, you're probably at least OK at critical thinking


This inspired me to research and download Brave Browser. Thanks Streisand Effect! So nice to have a browser that doesn't feel like bloatware


What on earth does that have to do with this topic?


> What on earth does that have to do with this topic?

Presumably, Brave doesn't include the Widevine DRM components from Chrome?


Super interesting, thanks for posting


No, you'd end up with Fruity Loops


That would have been a fair comparison 10 years ago. These days FL Studio is no less advanced than Ableton in some regards (e.g. the mixer, etc).


As a long time (15+yrs) user of both. FLS has better ergonomics in a lot of places. Especially piano roll (slide MIDI notes) and arrangement view (automation as standalone clip). Plus the razor tool, my god...

FLS doesn't have a max for live equivalent, but I'd guess 90% of people don't use MFL. The edison recording workflow is hot trash IMO, or else I'd pretty readily move back to FL.


> the razor tool

I really really enjoy using Ableton and have stuck with it for years now, but one of the first things that struck me once I swapped from FL Studio was how stupid it was that Ableton's piano roll lacked this fairly basic yet crucial tool..


I think this is a joke? Hopefully?


From the link,

> Eternal moral vigilance is no laughing matter.


Sounds like something someone who lacks the courage of their own convictions would ask ;)


Put your money where your mouth is. I accept Bitcoin and Stellar Lumens.


Can confirm it does


Well...Linux plus rootkit preventing you from doing what you want on a device you've paid for


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