You can also do it in Keynote. Just create hyperlinks between slides (which you can do with any shape, via the Inspector). Then export the presentation as a PDF, and the clickable image hyperlinks will be preserved in the PDF file. Then it's also very convenient for sharing with designers/developers/investors, etc.
Here's a really goofy and poorly-thought-out example as a proof of concept. It took about 10 minutes to make. http://goo.gl/AemLD (best viewed in Preview in single-page mode)
I launched the Pest Management Roundtable (http://pestroundtable.com) in February. After several months of good ol' fashioned hustling (mostly email marketing + telephone interviews and sales), I'm up to nearly $500 in monthly recurring revenue. It's not quite "ramen profitable" yet, but I've been picking up customers quickly the last 2 weeks, so at this rate I'll get it there within the month. A recent milestone was that last week I interviewed the owner of the 10th largest pest control company in the US (Joe Clark, of Clark Pest Control in California). He joined the Roundtable immediately following the interview.
Yeah, I'm an owner of http://www.isotope11.com and our designer threw it together in a couple of days. He's awesome, and he's leaving shortly, and we'll miss him :(
Yes, this area is called "Manhattan Valley". I lived there for two years while studying CS at Columbia and loved it. We had 5 guys in a 4-bedroom (actually 3BR with a walk-through room with an office that we used as a small bedroom) apartment at 108th St and Broadway. $3k/mo in rent. The location was amazing: 10 minute walk to Columbia, 3 minutes to the 1 train stop at 110th St, 2 minutes to Thai Market (my favorite Thai place in Manhattan).
Actually, Manhattan Valley is just to the south of Columbia. The area to the north where we are is called Manhattanville (http://en.wikipedia.org/wiki/Manhattanville), though most won't know that name.
Another tip for prospective New Yorkers: find out where filming permits are being issued. Film crews will stay away from the overly expensive (stuck-up-ish, NIMBY-ish) neighborhoods, but they also won't go anywhere overly risky. As a nice added bonus, typically the area will be picturesque (though not always).
For example: "Person of Interest" was filming in front of our building on Monday, episodes of "Blue Bloods" and "Gossip Girl" have filmed within a couple blocks, and the outdoor scenes at the end of Lady Gaga's video for "Marry the Night" were shot right by the Fairway 3 blocks away.