Super interesting - my friend has ME/CFS and/or Fibromyalgia and started GLP-1 but seemed to get only the negative side effects and not much benefit. Using Zepbound specifically.
Is the Modafinil used for alertness or a different off label purpose? I'm always interested in potential helpful interventions.
That reaction could very much be dose dependent. I think those in most need of the effect start out very hypersensitive to it and that reaction could easily obscure any benefits.
I use Modafinil and Amitryptiline as a rather unorthodox method for treating dysautonomia which seems to be an intrinsic precursor to ME/CFS, at least in my case where I have hEDS from a number of TNXB variants.
My overall theory is that a combination of anxiety disorders (genetic inability to ameliorate stress) pushes me into a Sympathetic state and keeps me there to the point that cytokines (or some undiscovered small molecule) are created by the immune system to knock me out of that state as a backup to other mechanisms that have stopped working. So I studied some psychopharmacology to design a drug combo that wouldn’t override the autonomic state so I could both work with my natural rhythms (using weaker ligands) and increase the magnitude of the swings so that I could spend enough time in the Parasympathetic state to obviate the need for the immune system backup. I take a lower dose of Modafinil (100mg started and stayed at this dose no apparent tolerance build) and am genetically very sensitive to caffeine so that and one coffee is enough to get me amped for the entire day, but I need amitryptiline to bring me back down to sleep (started as 25mg and many years later I’m at 125mg due to increasing tolerance). I do want to bring down my reliance on amitryptiline but I’m working crazy hours and figure I can wait to titrate down my dose later. I’ve been at this same dose for a year now so it’s at least not getting any worse).
Super interesting - friend is on a Adderall and Trazedone stack for energy/focus + sleep aid. Amitriptyline looks very interesting though I don't think they've tried that.
Thanks for the information, it's such a frustrating condition with a dearth of good information and research.
There are a billion options so I recommend just picking a few and practicing until you can tie them quickly without references. You'll start to understand hope knots in general work and be able to pick up other knots much easier.
Generally there Firms prize "first principles" thinking and don't put a ton of effort into leveraging previous engagements. Think of it like how engineers will throw out a solution and rebuild it rather than understand and build upon it.
It is also quite difficult to surface useful information amongst all the noise in the giant archive of documents
Oh no, that's not true at all. They care about data, and they will actually tell you themselves that they already did it for you - right after convincing you that you need to do it again.
The whole fanbase is wondering the same! They have done a variety of multimedia experiences beyond light shows at their festivals and New Years Eve shows so are no strangers to using different tech.
The most interesting thing will be how the improvisation is handled. A large chunk of Phish shows are all improvised which means no pre-programmed visuals. This is very different to U2 which has the entire show planned and programmed.
>Sanitizing your inputs has been known about for literally almost half a century that should just be default for developers at this point.
Except if you're a "stupid programmer", in which such defaults are irrelevant to you. In such cases, one can only hope they're relying on tooling that sanitizes as much as possible for them.
I'd say a more accurate metaphor would be "I'm in debt and decided to ignore my biggest high interest loan in order to fully pay off my smallest low interest loan so I feel good about something"
Sure it's good you have less debt but while you were resolving the small loan you were racking up massive interest on the big one
A million things. Of course, there's no hard date such that when you turn 40 then everything changes. It's just a rough age range.
I'll answer your question by repeating the most common things I've heard from others, not my own experience, in an attempt to reduce the error band by not having a sample size of 1.
By your 40s, you generally have at least a direction you're going. People tend to take you more seriously. You have a greater sense of what's actually important and what's not, and stop wasting energy getting as worked up by things that don't really matter. You are still young enough that you aren't yet battling many adverse effects of aging.
You also tend to be at your most physically attractive point. Your career path is likely to be established and less uncertain. Romantic partners tend to be more stable, so your love life brings more joy. Speaking of romantic partners... relationships are better because (as a friend of mine once put it) "sex isn't such a fucking emergency anymore". Your relationships tend to be more balanced. And so forth.
I think, really, it's an age where you have gained more perspective and are still young enough to use that to live a better life.
The ‘fuck it’ bucket.
You realize that life is here and you stop caring about the social constructs you’ve been part of.
Also, while you aren’t your virulent former self, you can do things well OR you can dive into something with the curiosity of a kid knowing you don’t need to be great.
Genuinely curious - how would you go about getting the parts and building something like a Bottle head amp? I been eyeing them up for a while and think the appeal is that they package everything up nicely, like buying a Lego kit. I assumed there was a standard "audiophile mark up" which sounds like it might be higher than I thought!
(Of all the tube amps I've built the Darling is still my favorite for the sound, simplicity. The tubes were cheap enough to find — used in the radios in WWII bombers, made obsolete by solid-state and military inventory was dumped on the market. Maybe 1-Watt in power though? You might be surprised how listenable that is through full-range drivers + powered sub.)
Excellent recommendations, I'll also add if you're not in a hurry Edcor makes excellent transformers (plate, filament, combo, output, interstage). Everything's custom made when you order it though.
Hammond Manufacturing makes a lot of applicable transformers for the mid-to-lower range of hifi and they're largely stock items.
See if you have local hamfests. Tons of tube stuff there.
Remember, it doesn't need to be an audio tube to pass audio! My most-used amplifier is built around a pair of 6T9 TV Compactron tubes (basically the IC of the tube world, multiple elements in a space saving package). The circuit came out of an old GE vacuum tube manual. As long as you don't tell the electrons (or audiophiles), they'll never know!
Edcor are made in the U.S., Hammond ... in Canada? Both excellent transformers - and probably the most expensive part of the build (the tubes I use go for much less than the iron).
Yeah, that was always the hard/expensive part, building tube stuff as a kid! Most of the junk radios and TVs I scrapped for parts were AC/DC sets with no transformer.
Audiophile/audiophoolery is certainly one mark up, but stuff made on that small scale generally needs huge markup just so the company making it turns a profit
I redid a lot of their original "Foreplay" preamps for the aforementioned audio shop -- they were available as a kit option and a lot of guys butchered the assembly, apparently. Back then, the power transformer was the cheapest combo plate/filament transformer from Antique Electronic Supply, but spraypainted black. That particular transformer was being loaded at like twice its filament current rating! Little stuff like that really bothered me.
Using an illicitly acquired copy of the Crack 1 (not 1.1) manual, I quickly priced out the guts (I excluded the case, screws/nuts/washers, and wires) on tubesandmore.com + digikey.com at $184.
Assuming the basic Crack 1.1 is similar, at a price of $349, that's $165 / 90% markup for packaging up the kit for you, a nice case, and very detailed assembly instructions with lots of pictures and warnings about the dangerous parts and whatnot.
(And $96 of that $184 is for the Hammond 273AZ transformer, which I found a post saying is similar to Bottlehead's custom PT-3, but I'm not too sure about that, and I wasn't going to spend too much time figuring out the specs for the PT-3. Perhaps a better choice of transformer would significantly cut down that cost.)
It isn't just social media, it is the combination of social media and smartphones. This makes social media far more pervasive in a teen's life.
See section 6[0] where they discuss how mental health declines correlating with Facebook coming to college campuses and with high speed internet arriving in cities for some evidence.
Speed will make accidents worse (deadlier). Acceleration will make accidents more likely. Sports cars flooring it from a stop, losing traction and hitting a telephone pole is like a whole genre of YouTube videos.
Acceleration does not make accidents more likely (well, technically, without the ability to accelerate, it'll be impossible to have a car crash, I guess?). Risky behavior makes accidents more likely. Not being able to control your machinery and still trying to push it to its limits makes accidents more likely. Here the problem is people who behave anti-social and ego-centrical. But that's behavior we like to generally encourage and then fix it by adding regulations around the most stupid things.
> Sports cars flooring it from a stop, losing traction
Traction control prevents this these days.
It still happens, of course, because idiots WANT to spin their tires and so turn off the traction control. But spinning tires != going fast. Usually sports cars flooring from a stop are interested in speed, not tire smoke, so the TC is still on.
That said, I know in my Model 3 Performance, I've floored it from a traffic light in the rain and had very little spin. It's insane how effective traction control is in an EV.
Is the Modafinil used for alertness or a different off label purpose? I'm always interested in potential helpful interventions.